What is the Difference Between Endotoxin and Exotoxin?
- Endotoxins are lipopolysaccharides, while exotoxins are soluble proteins produced by pathogenic bacteria.
- Both gram negative and gram positive bacteria produce exotoxins while endotoxins are produced by gram negative bacteria.
- Endotoxins cannot act as enzymes, but exotoxins can act as enzymes.
- Endotoxins are a part of the outer membrane of cell wall, whereas exotoxins are extracellular component.
- Endotoxins are less toxic than exotoxins.
- Exotoxins are specific to particular bacterial strain while endotoxins are not.
- Exotoxins are not heat stable, whereas endotoxins are heat stable.
- Endotoxins are poor antigens, whereas exotoxins are highly antigenic.
- By stimulating the immune system exotoxins produce antitoxins to neutralize the toxin while endotoxins do not produce antitoxins.
Endotoxin vs Exotoxin
Toxigenesis is the process of producing toxins by pathogenic bacteria. It is one of main mechanisms of developing diseases by bacteria. Two kinds of toxins; i.e. endotoxins and exotoxins are produced, and those can be distinguished by their chemical nature. Endotoxins are lipopolysaccharides and exotoxins are proteins.